QuickField

A new approach to field modelling

Main >> Support >> Webinars >> Pulsed electric fields for burn wound disinfection

Pulsed electric fields for burn wound disinfection. Numerical modeling using QuickField and experimental evidence in mice.

bacteria, pulsed electric field, disinfection, cell

Pulsed electric fields for burn wound disinfection

Emerging bacterial resistance to multiple drugs is an increasing problem in burn wound management. New non-pharmacologic interventions are needed for wound disinfection. Here we report on a novel physical method for disinfection: antiseptic pulsed electric field (PEF) applied externally to the infected wounds. In an animal model, we show that PEF can reduce the load of multidrug resistant Acinetobacter baumannii present in a full thickness burn wound by more than four orders of magnitude, as detected by bioluminescence imaging. Furthermore, using a finite element numerical model in QuickField, we demonstrate that PEF provides non-thermal, homogeneous, full thickness treatment for the burn wound, thus, overcoming the limitation of treatment depth for many topical antimicrobials.
These modeling tools and our in vivo results will be extremely useful for further translation of the PEF technology to the clinical setting, as they provide the essential elements for planning of electrode design and treatment protocol.

New version QuickField 6.6

Product
Order
Evaluation request
Editions
Version history
Packages
Components
Programming
Consulting
Applications
Industrial
Educational
Scientific
Sample problems
Success stories
Customers
Support
Webinars
Virtual Classroom
Online courses
Customer login
Glossary
QuickField help
FAQ
Downloads
QuickField Student Edition
User manual
Data Libraries
Video
Free tools
News
Product News
Events
Publications
Subscription
Contacts
Tera Analysis info
Resellers
Contact us
Online chat
About us